A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22 393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients
Identifieur interne : 004333 ( Main/Exploration ); précédent : 004332; suivant : 004334A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22 393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients
Auteurs : Prasanna Sooriakumaran [Royaume-Uni, Suède] ; Abhishek Srivastava [États-Unis] ; Shahrokh F. Shariat [États-Unis, Autriche] ; Phillip D. Strieker [Australie] ; Thomas Ahlering [États-Unis] ; Christopher G. Eden [Royaume-Uni] ; Peter N. Wiklund [Suède] ; Rafael Sanchez-Salas [France] ; Alexandre Mottrie [Belgique] ; David Lee [États-Unis] ; David E. Neal [Royaume-Uni] ; Reza Ghavamian [États-Unis] ; Peter Nyirady [Hongrie] ; Andreas Nilsson [Suède] ; Stefan Carlsson [Suède] ; Evanguelos Xylinas [États-Unis] ; Wolfgang Loidl [Autriche] ; Christian Seitz [Autriche] ; Paul Schramek [Autriche] ; Claus Roehrborn [États-Unis] ; Xavier Cathelineau [France] ; Douglas Skarecky [États-Unis] ; Greg Shaw [Royaume-Uni] ; Anne Warren [Royaume-Uni] ; Warick J. Delprado [Australie] ; Anne-Marie Haynes [Australie] ; Ewout Steyerberg [Pays-Bas] ; Monique J. Roobol [Pays-Bas] ; Ashutosh K. Tewari [États-Unis]Source :
- European urology [ 0302-2838 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Robotique, Homme, Télémédecine.
English descriptors
- KwdEn :
Abstract
Background: Positive surgical margins (PSMs) are a known risk factor for biochemical recurrence in patients with prostate cancer (PCa) and are potentially affected by surgical technique and volume. Objective: To investigate whether radical prostatectomy (RP) modality and volume affect PSM rates. Design, setting, and participants: Fourteen institutions in Europe, the United States, and Australia were invited to participate in this study, all of which retrospectively provided margins data on 9778 open RP, 4918 laparoscopic RP, and 7697 robotic RP patients operated on between January 2000 and October 2011. Outcome measurements and statistical analyses: The outcome measure was PSM rate. Multivariable logistic regression analyses and propensity score methods identified odds ratios for risk of a PSM for one modality compared with another, after adjustment for age, preoperative prostate-specific antigen, postoperative Gleason score, pathologic stage, and year of surgery. Classic adjustment using standard covariates was also implemented to compare PSM rates based on center volume for each minimally invasive surgical cohort. Results and limitations: Open RP patients had higher-risk PCa at time of surgery on average and were operated on earlier in the study time period on average, compared with minimally invasive cohorts. Crude margin rates were lowest for robotic RP (13.8%), intermediate for laparoscopic RP (16.3%), and highest for open RP (22.8%); significant differences persisted, although were ameliorated, after statistical adjustments. Lower-volume centers had increased risks of PSM compared with the highest-volume center for both laparoscopic RP and robotic RP. The study is limited by its nonrandomized nature; missing data across covariates, especially year of surgery in many of the open cohort cases; lack of standardized histologic processing and central pathology review; and lack of information regarding potential confounders such as patient comorbidity, nerve-sparing status, lymph node status, tumor volume, and individual surgeon caseload.
Affiliations:
- Australie, Autriche, Belgique, France, Hongrie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Hollande-Méridionale, Hongrie centrale, Nouvelle-Galles du Sud, Oxfordshire, Svealand, Vienne (Autriche), Île-de-France
- Budapest, Cambridge, Oxford, Paris, Rotterdam, Stockholm, Sydney, Vienne (Autriche)
- Université d'Oxford, Université de Cambridge
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22 393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients</title><author><name sortKey="Sooriakumaran, Prasanna" sort="Sooriakumaran, Prasanna" uniqKey="Sooriakumaran P" first="Prasanna" last="Sooriakumaran">Prasanna Sooriakumaran</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Surgical Intervention Trials Unit, Nuffield Department of Surgical Sciences, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Srivastava, Abhishek" sort="Srivastava, Abhishek" uniqKey="Srivastava A" first="Abhishek" last="Srivastava">Abhishek Srivastava</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Urology, Montefiore Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Shariat, Shahrokh F" sort="Shariat, Shahrokh F" uniqKey="Shariat S" first="Shahrokh F." last="Shariat">Shahrokh F. 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Strieker</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Ahlering, Thomas" sort="Ahlering, Thomas" uniqKey="Ahlering T" first="Thomas" last="Ahlering">Thomas Ahlering</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Urology, University of California-Irvine School of Medicine</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Eden, Christopher G" sort="Eden, Christopher G" uniqKey="Eden C" first="Christopher G." last="Eden">Christopher G. Eden</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Urology, Royal Surrey County Hospital</s1><s2>Guildford</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Guildford</wicri:noRegion></affiliation></author><author><name sortKey="Wiklund, Peter N" sort="Wiklund, Peter N" uniqKey="Wiklund P" first="Peter N." last="Wiklund">Peter N. Wiklund</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sanchez Salas, Rafael" sort="Sanchez Salas, Rafael" uniqKey="Sanchez Salas R" first="Rafael" last="Sanchez-Salas">Rafael Sanchez-Salas</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urology, L'Institut Mutualiste Montsouris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mottrie, Alexandre" sort="Mottrie, Alexandre" uniqKey="Mottrie A" first="Alexandre" last="Mottrie">Alexandre Mottrie</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital</s1><s2>Aalst</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Aalst</wicri:noRegion></affiliation></author><author><name sortKey="Lee, David" sort="Lee, David" uniqKey="Lee D" first="David" last="Lee">David Lee</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Urology, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA</wicri:noRegion></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Department of Uro-oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Uro-oncology Research Group, Cancer Research UK, Cambridge Research Institute</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Ghavamian, Reza" sort="Ghavamian, Reza" uniqKey="Ghavamian R" first="Reza" last="Ghavamian">Reza Ghavamian</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Urology, Montefiore Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Nyirady, Peter" sort="Nyirady, Peter" uniqKey="Nyirady P" first="Peter" last="Nyirady">Peter Nyirady</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Urology, Semmelweis University</s1><s2>Budapest</s2><s3>HUN</s3><sZ>13 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nilsson, Andreas" sort="Nilsson, Andreas" uniqKey="Nilsson A" first="Andreas" last="Nilsson">Andreas Nilsson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Carlsson, Stefan" sort="Carlsson, Stefan" uniqKey="Carlsson S" first="Stefan" last="Carlsson">Stefan Carlsson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Xylinas, Evanguelos" sort="Xylinas, Evanguelos" uniqKey="Xylinas E" first="Evanguelos" last="Xylinas">Evanguelos Xylinas</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Weill Cornell Medical College-New York Presbyterian Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>16 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Loidl, Wolfgang" sort="Loidl, Wolfgang" uniqKey="Loidl W" first="Wolfgang" last="Loidl">Wolfgang Loidl</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Urology, St. Vincent's Hospital</s1><s2>Linz</s2><s3>AUT</s3><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Linz</wicri:noRegion></affiliation></author><author><name sortKey="Seitz, Christian" sort="Seitz, Christian" uniqKey="Seitz C" first="Christian" last="Seitz">Christian Seitz</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Urology, Medical University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Schramek, Paul" sort="Schramek, Paul" uniqKey="Schramek P" first="Paul" last="Schramek">Paul Schramek</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Urology, Saint John of God Hospital</s1><s2>Vienna</s2><s3>AUT</s3><sZ>19 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Roehrborn, Claus" sort="Roehrborn, Claus" uniqKey="Roehrborn C" first="Claus" last="Roehrborn">Claus Roehrborn</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Urology, University of Texas Southwestern Medical Center</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas, TX</wicri:noRegion></affiliation></author><author><name sortKey="Cathelineau, Xavier" sort="Cathelineau, Xavier" uniqKey="Cathelineau X" first="Xavier" last="Cathelineau">Xavier Cathelineau</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urology, L'Institut Mutualiste Montsouris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Skarecky, Douglas" sort="Skarecky, Douglas" uniqKey="Skarecky D" first="Douglas" last="Skarecky">Douglas Skarecky</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Urology, University of California-Irvine School of Medicine</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Greg" sort="Shaw, Greg" uniqKey="Shaw G" first="Greg" last="Shaw">Greg Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Uro-oncology Research Group, Cancer Research UK, Cambridge Research Institute</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Warren, Anne" sort="Warren, Anne" uniqKey="Warren A" first="Anne" last="Warren">Anne Warren</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>24 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Delprado, Warick J" sort="Delprado, Warick J" uniqKey="Delprado W" first="Warick J." last="Delprado">Warick J. Delprado</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Haynes, Anne Marie" sort="Haynes, Anne Marie" uniqKey="Haynes A" first="Anne-Marie" last="Haynes">Anne-Marie Haynes</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Steyerberg, Ewout" sort="Steyerberg, Ewout" uniqKey="Steyerberg E" first="Ewout" last="Steyerberg">Ewout Steyerberg</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Public Health, Erasmus MC-University Medical Center Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Public Health, Erasmus MC-University Medical Center Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Tewari, Ashutosh K" sort="Tewari, Ashutosh K" uniqKey="Tewari A" first="Ashutosh K." last="Tewari">Ashutosh K. Tewari</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Weill Cornell Medical College-New York Presbyterian Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>16 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0223163</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0223163 INIST</idno><idno type="RBID">Pascal:14-0223163</idno><idno type="wicri:Area/PascalFrancis/Corpus">000267</idno><idno type="wicri:Area/PascalFrancis/Curation">005B96</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000484</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000484</idno><idno type="wicri:doubleKey">0302-2838:2014:Sooriakumaran P:a:multinational:multi</idno><idno type="wicri:Area/Main/Merge">004408</idno><idno type="wicri:Area/Main/Curation">004333</idno><idno type="wicri:Area/Main/Exploration">004333</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A Multinational, Multi-institutional Study Comparing Positive Surgical Margin Rates Among 22 393 Open, Laparoscopic, and Robot-assisted Radical Prostatectomy Patients</title><author><name sortKey="Sooriakumaran, Prasanna" sort="Sooriakumaran, Prasanna" uniqKey="Sooriakumaran P" first="Prasanna" last="Sooriakumaran">Prasanna Sooriakumaran</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Surgical Intervention Trials Unit, Nuffield Department of Surgical Sciences, University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Srivastava, Abhishek" sort="Srivastava, Abhishek" uniqKey="Srivastava A" first="Abhishek" last="Srivastava">Abhishek Srivastava</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Urology, Montefiore Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Shariat, Shahrokh F" sort="Shariat, Shahrokh F" uniqKey="Shariat S" first="Shahrokh F." last="Shariat">Shahrokh F. Shariat</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Weill Cornell Medical College-New York Presbyterian Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>16 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Urology, Medical University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Strieker, Phillip D" sort="Strieker, Phillip D" uniqKey="Strieker P" first="Phillip D." last="Strieker">Phillip D. Strieker</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Ahlering, Thomas" sort="Ahlering, Thomas" uniqKey="Ahlering T" first="Thomas" last="Ahlering">Thomas Ahlering</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Urology, University of California-Irvine School of Medicine</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Eden, Christopher G" sort="Eden, Christopher G" uniqKey="Eden C" first="Christopher G." last="Eden">Christopher G. Eden</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Urology, Royal Surrey County Hospital</s1><s2>Guildford</s2><s3>GBR</s3><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Guildford</wicri:noRegion></affiliation></author><author><name sortKey="Wiklund, Peter N" sort="Wiklund, Peter N" uniqKey="Wiklund P" first="Peter N." last="Wiklund">Peter N. Wiklund</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sanchez Salas, Rafael" sort="Sanchez Salas, Rafael" uniqKey="Sanchez Salas R" first="Rafael" last="Sanchez-Salas">Rafael Sanchez-Salas</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urology, L'Institut Mutualiste Montsouris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Mottrie, Alexandre" sort="Mottrie, Alexandre" uniqKey="Mottrie A" first="Alexandre" last="Mottrie">Alexandre Mottrie</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Urology, Onze-Lieve-Vrouwziekenhuis Hospital</s1><s2>Aalst</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Aalst</wicri:noRegion></affiliation></author><author><name sortKey="Lee, David" sort="Lee, David" uniqKey="Lee D" first="David" last="Lee">David Lee</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Urology, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA</wicri:noRegion></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Department of Uro-oncology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Uro-oncology Research Group, Cancer Research UK, Cambridge Research Institute</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Ghavamian, Reza" sort="Ghavamian, Reza" uniqKey="Ghavamian R" first="Reza" last="Ghavamian">Reza Ghavamian</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Urology, Montefiore Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Nyirady, Peter" sort="Nyirady, Peter" uniqKey="Nyirady P" first="Peter" last="Nyirady">Peter Nyirady</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Urology, Semmelweis University</s1><s2>Budapest</s2><s3>HUN</s3><sZ>13 aut.</sZ></inist:fA14><country>Hongrie</country><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nilsson, Andreas" sort="Nilsson, Andreas" uniqKey="Nilsson A" first="Andreas" last="Nilsson">Andreas Nilsson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Carlsson, Stefan" sort="Carlsson, Stefan" uniqKey="Carlsson S" first="Stefan" last="Carlsson">Stefan Carlsson</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Molecular Medicine and Surgery, Karolinska Institutet</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>1 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Xylinas, Evanguelos" sort="Xylinas, Evanguelos" uniqKey="Xylinas E" first="Evanguelos" last="Xylinas">Evanguelos Xylinas</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Weill Cornell Medical College-New York Presbyterian Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>16 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Loidl, Wolfgang" sort="Loidl, Wolfgang" uniqKey="Loidl W" first="Wolfgang" last="Loidl">Wolfgang Loidl</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Urology, St. Vincent's Hospital</s1><s2>Linz</s2><s3>AUT</s3><sZ>17 aut.</sZ></inist:fA14><country>Autriche</country><wicri:noRegion>Linz</wicri:noRegion></affiliation></author><author><name sortKey="Seitz, Christian" sort="Seitz, Christian" uniqKey="Seitz C" first="Christian" last="Seitz">Christian Seitz</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Urology, Medical University of Vienna</s1><s2>Vienna</s2><s3>AUT</s3><sZ>3 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Schramek, Paul" sort="Schramek, Paul" uniqKey="Schramek P" first="Paul" last="Schramek">Paul Schramek</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Urology, Saint John of God Hospital</s1><s2>Vienna</s2><s3>AUT</s3><sZ>19 aut.</sZ></inist:fA14><country>Autriche</country><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Roehrborn, Claus" sort="Roehrborn, Claus" uniqKey="Roehrborn C" first="Claus" last="Roehrborn">Claus Roehrborn</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Urology, University of Texas Southwestern Medical Center</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Dallas, TX</wicri:noRegion></affiliation></author><author><name sortKey="Cathelineau, Xavier" sort="Cathelineau, Xavier" uniqKey="Cathelineau X" first="Xavier" last="Cathelineau">Xavier Cathelineau</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urology, L'Institut Mutualiste Montsouris</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>21 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Skarecky, Douglas" sort="Skarecky, Douglas" uniqKey="Skarecky D" first="Douglas" last="Skarecky">Douglas Skarecky</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Urology, University of California-Irvine School of Medicine</s1><s2>Irvine, CA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>22 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Irvine, CA</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Greg" sort="Shaw, Greg" uniqKey="Shaw G" first="Greg" last="Shaw">Greg Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Uro-oncology Research Group, Cancer Research UK, Cambridge Research Institute</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>11 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Warren, Anne" sort="Warren, Anne" uniqKey="Warren A" first="Anne" last="Warren">Anne Warren</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>24 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Delprado, Warick J" sort="Delprado, Warick J" uniqKey="Delprado W" first="Warick J." last="Delprado">Warick J. Delprado</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Haynes, Anne Marie" sort="Haynes, Anne Marie" uniqKey="Haynes A" first="Anne-Marie" last="Haynes">Anne-Marie Haynes</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Prostate Cancer Centre, St. Vincent's Clinic</s1><s2>Sydney</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Steyerberg, Ewout" sort="Steyerberg, Ewout" uniqKey="Steyerberg E" first="Ewout" last="Steyerberg">Ewout Steyerberg</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Public Health, Erasmus MC-University Medical Center Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. Roobol</name><affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Department of Public Health, Erasmus MC-University Medical Center Rotterdam</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Tewari, Ashutosh K" sort="Tewari, Ashutosh K" uniqKey="Tewari A" first="Ashutosh K." last="Tewari">Ashutosh K. Tewari</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Urology, Weill Cornell Medical College-New York Presbyterian Hospital</s1><s2>New York, NY</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>16 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">European urology</title><title level="j" type="abbreviated">Eur. urol.</title><idno type="ISSN">0302-2838</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European urology</title><title level="j" type="abbreviated">Eur. urol.</title><idno type="ISSN">0302-2838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Comparative study</term><term>Endoscopic surgery</term><term>Human</term><term>Laparoscopic surgery</term><term>Laparoscopy</term><term>Nephrology</term><term>Prostatectomy</term><term>Rate</term><term>Robotics</term><term>Surgical margin</term><term>Telemedicine</term><term>Treatment</term><term>Urology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Marge chirurgicale</term><term>Etude comparative</term><term>Chirurgie endoscopique</term><term>Taux</term><term>Prostatectomie</term><term>Coeliochirurgie</term><term>Robotique</term><term>Homme</term><term>Laparoscopie</term><term>Télémédecine</term><term>Néphrologie</term><term>Urologie</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Robotique</term><term>Homme</term><term>Télémédecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Positive surgical margins (PSMs) are a known risk factor for biochemical recurrence in patients with prostate cancer (PCa) and are potentially affected by surgical technique and volume. Objective: To investigate whether radical prostatectomy (RP) modality and volume affect PSM rates. Design, setting, and participants: Fourteen institutions in Europe, the United States, and Australia were invited to participate in this study, all of which retrospectively provided margins data on 9778 open RP, 4918 laparoscopic RP, and 7697 robotic RP patients operated on between January 2000 and October 2011. Outcome measurements and statistical analyses: The outcome measure was PSM rate. Multivariable logistic regression analyses and propensity score methods identified odds ratios for risk of a PSM for one modality compared with another, after adjustment for age, preoperative prostate-specific antigen, postoperative Gleason score, pathologic stage, and year of surgery. Classic adjustment using standard covariates was also implemented to compare PSM rates based on center volume for each minimally invasive surgical cohort. Results and limitations: Open RP patients had higher-risk PCa at time of surgery on average and were operated on earlier in the study time period on average, compared with minimally invasive cohorts. Crude margin rates were lowest for robotic RP (13.8%), intermediate for laparoscopic RP (16.3%), and highest for open RP (22.8%); significant differences persisted, although were ameliorated, after statistical adjustments. Lower-volume centers had increased risks of PSM compared with the highest-volume center for both laparoscopic RP and robotic RP. The study is limited by its nonrandomized nature; missing data across covariates, especially year of surgery in many of the open cohort cases; lack of standardized histologic processing and central pathology review; and lack of information regarding potential confounders such as patient comorbidity, nerve-sparing status, lymph node status, tumor volume, and individual surgeon caseload.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Belgique</li><li>France</li><li>Hongrie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Hollande-Méridionale</li><li>Hongrie centrale</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Svealand</li><li>Vienne (Autriche)</li><li>Île-de-France</li></region><settlement><li>Budapest</li><li>Cambridge</li><li>Oxford</li><li>Paris</li><li>Rotterdam</li><li>Stockholm</li><li>Sydney</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sooriakumaran, Prasanna" sort="Sooriakumaran, Prasanna" uniqKey="Sooriakumaran P" first="Prasanna" last="Sooriakumaran">Prasanna Sooriakumaran</name></region><name sortKey="Eden, Christopher G" sort="Eden, Christopher G" uniqKey="Eden C" first="Christopher G." last="Eden">Christopher G. Eden</name><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E." last="Neal">David E. Neal</name><name sortKey="Shaw, Greg" sort="Shaw, Greg" uniqKey="Shaw G" first="Greg" last="Shaw">Greg Shaw</name><name sortKey="Warren, Anne" sort="Warren, Anne" uniqKey="Warren A" first="Anne" last="Warren">Anne Warren</name></country><country name="Suède"><region name="Svealand"><name sortKey="Sooriakumaran, Prasanna" sort="Sooriakumaran, Prasanna" uniqKey="Sooriakumaran P" first="Prasanna" last="Sooriakumaran">Prasanna Sooriakumaran</name></region><name sortKey="Carlsson, Stefan" sort="Carlsson, Stefan" uniqKey="Carlsson S" first="Stefan" last="Carlsson">Stefan Carlsson</name><name sortKey="Nilsson, Andreas" sort="Nilsson, Andreas" uniqKey="Nilsson A" first="Andreas" last="Nilsson">Andreas Nilsson</name><name sortKey="Wiklund, Peter N" sort="Wiklund, Peter N" uniqKey="Wiklund P" first="Peter N." last="Wiklund">Peter N. Wiklund</name></country><country name="États-Unis"><noRegion><name sortKey="Srivastava, Abhishek" sort="Srivastava, Abhishek" uniqKey="Srivastava A" first="Abhishek" last="Srivastava">Abhishek Srivastava</name></noRegion><name sortKey="Ahlering, Thomas" sort="Ahlering, Thomas" uniqKey="Ahlering T" first="Thomas" last="Ahlering">Thomas Ahlering</name><name sortKey="Ghavamian, Reza" sort="Ghavamian, Reza" uniqKey="Ghavamian R" first="Reza" last="Ghavamian">Reza Ghavamian</name><name sortKey="Lee, David" sort="Lee, David" uniqKey="Lee D" first="David" last="Lee">David Lee</name><name sortKey="Roehrborn, Claus" sort="Roehrborn, Claus" uniqKey="Roehrborn C" first="Claus" last="Roehrborn">Claus Roehrborn</name><name sortKey="Shariat, Shahrokh F" sort="Shariat, Shahrokh F" uniqKey="Shariat S" first="Shahrokh F." last="Shariat">Shahrokh F. Shariat</name><name sortKey="Skarecky, Douglas" sort="Skarecky, Douglas" uniqKey="Skarecky D" first="Douglas" last="Skarecky">Douglas Skarecky</name><name sortKey="Tewari, Ashutosh K" sort="Tewari, Ashutosh K" uniqKey="Tewari A" first="Ashutosh K." last="Tewari">Ashutosh K. Tewari</name><name sortKey="Xylinas, Evanguelos" sort="Xylinas, Evanguelos" uniqKey="Xylinas E" first="Evanguelos" last="Xylinas">Evanguelos Xylinas</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Shariat, Shahrokh F" sort="Shariat, Shahrokh F" uniqKey="Shariat S" first="Shahrokh F." last="Shariat">Shahrokh F. Shariat</name></region><name sortKey="Loidl, Wolfgang" sort="Loidl, Wolfgang" uniqKey="Loidl W" first="Wolfgang" last="Loidl">Wolfgang Loidl</name><name sortKey="Schramek, Paul" sort="Schramek, Paul" uniqKey="Schramek P" first="Paul" last="Schramek">Paul Schramek</name><name sortKey="Seitz, Christian" sort="Seitz, Christian" uniqKey="Seitz C" first="Christian" last="Seitz">Christian Seitz</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Strieker, Phillip D" sort="Strieker, Phillip D" uniqKey="Strieker P" first="Phillip D." last="Strieker">Phillip D. Strieker</name></region><name sortKey="Delprado, Warick J" sort="Delprado, Warick J" uniqKey="Delprado W" first="Warick J." last="Delprado">Warick J. Delprado</name><name sortKey="Haynes, Anne Marie" sort="Haynes, Anne Marie" uniqKey="Haynes A" first="Anne-Marie" last="Haynes">Anne-Marie Haynes</name></country><country name="France"><region name="Île-de-France"><name sortKey="Sanchez Salas, Rafael" sort="Sanchez Salas, Rafael" uniqKey="Sanchez Salas R" first="Rafael" last="Sanchez-Salas">Rafael Sanchez-Salas</name></region><name sortKey="Cathelineau, Xavier" sort="Cathelineau, Xavier" uniqKey="Cathelineau X" first="Xavier" last="Cathelineau">Xavier Cathelineau</name></country><country name="Belgique"><noRegion><name sortKey="Mottrie, Alexandre" sort="Mottrie, Alexandre" uniqKey="Mottrie A" first="Alexandre" last="Mottrie">Alexandre Mottrie</name></noRegion></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Nyirady, Peter" sort="Nyirady, Peter" uniqKey="Nyirady P" first="Peter" last="Nyirady">Peter Nyirady</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Steyerberg, Ewout" sort="Steyerberg, Ewout" uniqKey="Steyerberg E" first="Ewout" last="Steyerberg">Ewout Steyerberg</name></region><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J." last="Roobol">Monique J. 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